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Trial Specifics:
This trial is designed to evaluate the safety and preliminary anti-cancer activity of a novel, monoclonal antibody in dogs with measurable cancer. The antibody is administered IV by the study staff every 28 days for up to 5 treatments. There is no placebo in this trial. An estimated 30 client-owned dogs with Lymphoma, Melanoma, or Mast Cell Tumors will be enrolled. Visits will be required when the dogs begin the study, at Day 14, Day 28, and monthly thereafter for a total trial period of 140 days.

Trial Funding:
The trial is fully funded for the full trial duration (140 days), including the antibody and trial-related procedures.

Trial Eligibility:
Dogs with one of the following cancers may be enrolled if they meet the specific criteria for each cancer:

Mast Cell tumors

  • At least one measurable skin tumor +/- metastatic lymph node(s) > 2 cm
  • No intraabdominal metastasis
  • Prior therapy accepted with washout times to be discussed with the participating site


  • At least one measurable malignant tumor in the oral cavity, digit, skin +/- metastatic lymph node > 2 cm
  • No pulmonary metastasis
  • Prior therapy accepted with washout times to be discussed with participating site


  • All stages accepted but must have at least one measurable peripheral lymph node > 2 cm
  • No pulmonary or gastrointestinal involvement
  • Disseminated B or T-cell lymphoma (not epitheliotrophic)
  • Newly diagnosed or dogs that have completed no more than one chemotherapy protocol

If you are interested in having your pet be evaluated for this trial, please contact Dr. Dennis Bailey, Oncology

It is upsetting to suspect or learn that your pet has cancer. The Oncology service at Oradell Animal Hospital is here to support you. We understand your concerns and will work tirelessly to help you through this difficult time.

Our focus is to provide you with an accurate diagnosis, apprise you of all the various treatment options, and ensure that all of your questions are answered. By working closely with the Surgery and Internal Medicine departments, we can determine the type and extent of the cancer in your individual pet so that a treatment plan that is best suited to your pet’s needs can be developed.

Services include:

  • Diagnostic imaging – Radiography, Ultrasound, MRI
  • Bone marrow aspirates
  • Biopsies
  • Nutritional Support
  • Chemotherapy administration

Diseases treated include:

  • Lymphoma and leukemia
  • Mast cell tumors and other skin tumors
  • Bladder tumors (e.g. transitional cell carcinoma)
  • Splenic tumors (e.g. hemangiosarcoma)
  • Bone tumors (e.g. osteosarcoma)
  • Soft tissue sarcomas
  • Vaccine-associated sarcomas
  • Mammary tumors
  • Intestinal tract tumors (from mouth to anal sacs, including liver)
  • Respiratory tract tumors (from nose to lungs)
  • Histiocytic tumors

If you would like to have your pet evaluated by the oncology department, please contact the front desk to make an appointment. If you or your veterinarian feels that your pet is critical and cannot wait for an appointment, your pet can be admitted through the emergency service, 24 hours a day and will then be evaluated by the oncology department when they are in the hospital.